Impact of homeopathic remedies on the expression of lineage differentiation genes: an approach using embryonic stem cells

Well-documented studies of the potential effects and safety of homeopathic medicines in pregnancy are required. In this study, specific genes were studied which could serve as biomarkers for specification of three lineages to predict the safety of homeopathic remedies using mouse embryonic stem (ES) cells. Thus, the present work was to study the effects of homeopathic remedies taken during pregnancy using ES cells as the model. Continue reading

Replications of fundamental research models in ultra high dilutions 1994 and 2015 – update on a bibliometric study

This paper focuses exclusively on experimental models with ultra high dilutions (i.e. beyond 10−23) that have been submitted to replication scrutiny. It updates previous surveys, considers suggestions made by the research community and compares the state of replication in 1994 with that in 2015. Continue reading

Update on preliminary elements of a theory of ultra high dilutions

The different mechanisms: A. of the interaction between the molecular mother substance and the solvent water or ethanol B. of the storage of molecule-specific information in the solvent. C. the physiological basis of the sensitivity of the living organism towards an ultra high dilution (UHD). D. the mechanism of the interaction of the test dilution with the organism are largely unknown. Several ideas have been postulated, and experiments to test them carried out in physics and in biology. Continue reading

Wheat and ultra high diluted silver nitrate – further experiments and re-analysis of data

Since 1926, an influence of a dilution of silver nitrate (24x) on the growth of coleoptiles of wheat seedlings was described. The aim of the study discussed here is the critical proof of the reliability of a test system which has been quoted as a basic model for the research on homoeopathy for decades. Continue reading

Ultra High Dilution – Physiology and Physics comes of age

This special issue of Homeopathy marks the 21st anniversary of the 1994 publication of the book ‘Ultra High Dilution – Physiology and Physics’ edited by Christian Endler and Jürgen Schulte.1 That seminal volume, featuring 26 contributions from authors of diverse scientific backgrounds, was a landmark in the evolution in research in homeopathy: the first multi-disciplinary work to address the how and why of the actions of ultra high dilutions. Continue reading

Polycrystalline structures formed in evaporating droplets as a parameter to test the action of 30c action in a wheat seed model

Polycrystalline structures formed inside evaporating droplets of different biological fluids have been shown sensitive towards various influences, including ultra high dilutions (UHDs), representing so a new approach potentially useful for basic research in homeopathy. In the present study we tested on a wheat seed model Zincum metallicum 30c efficacy versus lactose 30c and water. Continue reading

Polycrystalline structures formed in evaporating droplets as a parameter to test the action of 30c in a wheat seed model

Polycrystalline structures formed inside evaporating droplets of different biological fluids have been shown sensitive towards various influences, including ultra high dilutions (UHDs), representing so a new approach potentially useful for basic research in homeopathy. In the present study we tested on a wheat seed model Zincum metallicum 30c efficacy versus lactose 30c and water. Continue reading

Wheat and ultra high diluted gibberellic acid – further experiments and re-analysis of data

Following studies (a) on wheat seedlings and ultra high diluted silver nitrate, and (b) on amphibians and an ultra high diluted hormone, (c) a bio-assay on wheat and extremely diluted gibberellic acid was standardized. This assay was intended to combine the easy-to-handle aspect of (a) and biologically interesting aspects of (b). The purpose of the data analysis presented here was to investigate the influence of an extreme dilution of gibberellic acid on wheat stalk length and to determine the influence of external factors on the experimental outcome. Continue reading

A randomized controlled trial comparing Pentazocine and for labor pain relief

Traditional birth attendants in Pakistan sometimes use a homeopathic remedy, Chamomilla for labor pain relief. Our study compares this homeopathic remedy for pain relief in labor with a commonly used parenteral analgesic in a hospital setting. No systematic study has been conducted previously to study the effect of chamomile, which may be affordable and available in community settings. Continue reading

Homeopathic has dual effects on the inflammatory response in the mouse preosteoblastic cell line MC3T3-e1

Homeopathic remedy Rhus toxicodendron (Rhus tox) is used for several symptoms including skin irritations, rheumatic pains, mucous membrane afflictions, and typhoid type fever. Previously, we reported that Rhus tox treatment increased the cyclooxygenase-2 (COX-2) mRNA expression in primary cultured mouse chondrocytes. Continue reading

Electromagnetic and magnetic vector potential bio-information and water

This work developed over the past 40 years starting from dielectric measurements on enzymes and the subsequent finding that the measurements were affected by electric, magnetic, electromagnetic fields and quantum fields. A request for help in the diagnosis and therapy of chemically sensitive patients who had become sensitive to their electromagnetic environment came in 1982. The same symptoms could be provoked by a chemical or a frequency challenge and this led to an appreciation of the synergy between chemical and frequency environmental sensitivities. Continue reading

Standardization of homeopathic mother tincture of and correlation of its flavonoid markers with the biological activity

Standardization and quality control of homeopathic drugs is very challenging. As mother tinctures are derived from complex natural resources, there is a need of systematic evaluation of chemical markers which correlate with the proposed biological activities of mother tinctures. Continue reading

Scientific proving of ultra high dilutions on humans

Homeopathic drug provings or pathogenetic trials (HPTs) are the pillar of homeopathy. This review summarizes the authors’ findings and interpretations derived from a series of homeopathic drug proving between 1994 and 2015. It gives an overview over a series of attempts to use modern scientific experimental methodology to answer the question, whether such HPTs produce symptoms in healthy volunteers that can be distinguished from placebo symptoms. Continue reading

Bone computed tomography mineral content evaluation in chickens: effects of substances in homeopathic concentration

Ninety-six cobb race chickens were equally divided in 4 groups and randomly assigned to receive a standard treatment feed + homeopathic concentrations of Symphytum (S.) officinalis (9CH), or standard treatment feed + homeopathic concentrations of Tricalcarea (4CH), or standard treatment feed + homeopathic concentrations of Calcarea (C.) carbonica (30CH) or a placebo (the same feed but without any homeopathic compound) in order to assess the ability of the homeopathic compounds to increase the concentration of calcium hydroxyapatite in the sternal spongy bone tissue. Continue reading

Use of homeopathy in organic dairy farming in Spain

Organic farming principles promote the use of unconventional therapies as an alternative to chemical substances (which are limited by organic regulations), with homeopathy being the most extensive. Traditionally, Spain has had little faith in homeopathy but its use in organic farming is growing. Fifty-six Spanish organic dairy farmers were interviewed to obtain what we believe to be the first data on the use of homeopathy in organic dairy cattle in Spain. Only 32% of farms use some sort of alternative therapy (16.1% homeopathy, 10.7% phytotherapy and 5.3% using both therapies) and interestingly, a clear geographical pattern showing a higher use towards the East (similar to that in the human population) was observed. Continue reading